NERVE GROWTH-FACTOR REVISITED

被引：90

作者：

BRADSHAW, RA

BLUNDELL, TL

LAPATTO, R

MCDONALD, NQ

MURRAYRUST, J

机构：

[1] UNIV LONDON BIRKBECK COLL,ICRF,STRUCT MOLEC BIOL UNIT,LONDON WC1E 7HX,ENGLAND

[2] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,LONDON WC1E 7HX,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 02期

关键词：

D O I：

10.1016/0968-0004(93)90052-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.

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页码：48 / 52

页数：5

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