COMPETITIVE-BINDING STUDIES WITH MULTIPLE SITES EFFECTS ARISING FROM DEPLETION OF THE FREE RADIOLIGAND

被引：30

作者：

WELLS, JW ^{[1
]}

BIRDSALL, NJM ^{[1
]}

BURGEN, ASV ^{[1
]}

HULME, EC ^{[1
]}

机构：

[1] NATL INST MED RES,DIV MOLEC PHARMACOL,LONDON NW7 1AA,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1980年 / 632卷 / 03期

关键词：

D O I：

10.1016/0304-4165(80)90242-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：464 / 469

页数：6

共 9 条

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[2]

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BURGEN, ASV ;

HULME, EC ;

WELLS, JW .

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[4] QUANTITATIVE ASPECTS OF HORMONE-RECEPTOR INTERACTIONS OF HIGH AFFINITY - EFFECT OF RECEPTOR CONCENTRATION AND MEASUREMENT OF DISSOCIATION-CONSTANTS OF LABELED AND UNLABELED HORMONES [J].

CHANG, KJ ;

JACOBS, S ;

CUATRECASAS, P .

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[6]

HULME EC, 1978, MOL PHARMACOL, V14, P737

[7] ESTIMATION OF HORMONE RECEPTOR AFFINITY BY COMPETITIVE DISPLACEMENT OF LABELED LIGAND - EFFECT OF CONCENTRATION OF RECEPTOR AND OF LABELED LIGAND [J].

JACOBS, S ;

CHANG, KJ ;

CUATRECASAS, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (02) :687-692

[8] AN ALGORITHM FOR LEAST-SQUARES ESTIMATION OF NONLINEAR PARAMETERS [J].

MARQUARDT, DW .

JOURNAL OF THE SOCIETY FOR INDUSTRIAL AND APPLIED MATHEMATICS, 1963, 11 (02) :431-441

[9]

WELLS JW, 1978, P CAN FED BIOL SOC, V21, P215

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