HIPPOCAMPAL NERVE GROWTH-FACTOR LEVELS ARE RELATED TO SPATIAL-LEARNING ABILITY IN AGED RATS

被引：87

作者：

HENRIKSSON, BG

SODERSTROM, S

GOWER, AJ

EBENDAL, T

WINBLAD, B

MOHAMMED, AH

机构：

[1] KAROLINSKA INST,HUDDINGE UNIV HOSP,ALZHEIMERS DIS RES CTR,DEPT GERIATR MED,S-14186 HUDDINGE,SWEDEN

[2] UNIV UPPSALA,DEPT DEV BIOL,S-75105 UPPSALA,SWEDEN

[3] UNION CHIM BELGE SA,PHARMACEUT SECTOR,BRAINE LALLEUD,BELGIUM

来源：

BEHAVIOURAL BRAIN RESEARCH | 1992年 / 48卷 / 01期

关键词：

AGING; NERVE GROWTH FACTOR; HIPPOCAMPUS; SPATIAL LEARNING; RAT;

D O I：

10.1016/S0166-4328(05)80134-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Brain nerve growth factor (NGF) was determined in two groups of aged rats: 'good' and 'poor' performers. The animals were selected out of a population of 40 aged rats (26-28 months old) trained in a spatial learning task. Animals performing well in the test had significantly higher NGF in the hippocampus when compared to 'poor' performers. No differences in the levels of NGF were found in the cortex, septum and cerebellum. The results implicate hippocampal NGF in cognitive functioning of aged rats, and suggests that the forebrain cholinergic neuronal atrophy which has been observed in cognitively impaired aged rats may be due to reduced availability of target-derived NGF.

引用

页码：15 / 20

页数：6

共 64 条

[11] AMELIORATION OF CHOLINERGIC NEURON ATROPHY AND SPATIAL MEMORY IMPAIRMENT IN AGED RATS BY NERVE GROWTH-FACTOR [J].