PROSTAGLANDINS SENSITIZE NOCICEPTORS IN CELL-CULTURE

被引：115

作者：

PITCHFORD, S

LEVINE, JD

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,DIV RHEUMATOL,U-426,BOX 0724,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT ANAT,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT ORAL & MAXILLOFACIAL SURG,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DIV NEUROSCI,SAN FRANCISCO,CA 94143

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 01期

关键词：

PROSTAGLANDIN; PRIMARY AFFERENT NOCICEPTOR; CELL CULTURE; PAIN; HYPERALGESIA; CAPSAICIN; WHOLE-CELL PATCH CLAMP; CYCLIC ADENOSINE MONOPHOSPHATE 2ND MESSENGER;

D O I：

10.1016/0304-3940(91)90444-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the whole cell patch clamp technique, a population of nociceptors were identified, by virtue of their small size and capsaicin responsitivity. Response to capsaicin was increased following treatment with the hyperalgesic prostaglandins, PGE2 and PGI2. Treatment of the cells with the cyclic adenosine monophosphate (cAMP) analogues, 8 bromo cAMP and dibutryl cAMP, also resulted in an increase in the capsaicin-induced currents. The effects of the cAMP analogues were greater than that produced by prostaglandin treatment. We conclude that PGE2 and PGI2 act directly on nociceptors, with cAMP as second messenger, to sensitize them to noxious stimulation.

引用

页码：105 / 108

页数：4

共 22 条

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