THE E5 TRANSFORMING PROTEINS OF THE PAPILLOMAVIRUSES

被引：11

作者：

DIMAIO, D

PETTI, L

HWANG, ES

机构：

[1] Department of Genetics, Yale University School of Medicine, New Haven, CT 06510

来源：

SEMINARS IN VIROLOGY | 1994年 / 5卷 / 05期

关键词：

RECEPTORS; SIGNAL TRANSDUCTION; KERATINOCYTES; PDGF RECEPTOR; TRANSFORMATION;

D O I：

10.1006/smvy.1994.1041

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The E5 proteins are short, hydrophobic transforming proteins encoded by many of the papillomaviruses. The 44 amino acid E5 protein of bovine papillomavirus efficiently transforms cultured fibroblasts and interacts with a variety of cellular proteins. Considerable evidence implicates the PDGF beta receptor as an important mediator of the transforming activity of the BPV E5 protein in fibroblasts. Other potential targets of the BPV E5 protein include the EGF receptor, a subunit of the the vacuolar H+ - ATPase, and a protein related to alpha-adaplin. The E5 transforming proteins of the human papillomaviruses may interact with similar cellular targets in keratinocytes.

引用

页码：369 / 379

页数：11

共 52 条

[1] BERGMAN P, 1988, ONCOGENE, V2, P453
[2] USE OF A RAPID, EFFICIENT INOCULATION METHOD TO INDUCE PAPILLOMAS BY COTTONTAIL RABBIT PAPILLOMAVIRUS DNA SHOWS THAT THE E7 GENE IS REQUIRED
BRANDSMA, JL
YANG, ZH
BARTHOLD, SW
JOHNSON, EA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) : 4816 - 4820
[3] THE PUTATIVE-E5 OPEN READING FRAME OF COTTONTAIL RABBIT PAPILLOMAVIRUS IS DISPENSABLE FOR PAPILLOMA FORMATION IN DOMESTIC RABBITS
BRANDSMA, JL
YANG, ZH
DIMAIO, D
BARTHOLD, SW
JOHNSON, E
XIAO, W
[J]. JOURNAL OF VIROLOGY, 1992, 66 (10) : 6204 - 6207
[4] INFECTIOUS VIRUS-REPLICATION IN PAPILLOMAS INDUCED BY MOLECULARLY CLONED COTTONTAIL RABBIT PAPILLOMAVIRUS DNA
BRANDSMA, JL
XIAO, W
[J]. JOURNAL OF VIROLOGY, 1993, 67 (01) : 567 - 571
[5] GENETIC AND BIOCHEMICAL DEFINITION OF THE BOVINE PAPILLOMAVIRUS E5 TRANSFORMING PROTEIN
BURKHARDT, A
DIMAIO, D
SCHLEGEL, R
[J]. EMBO JOURNAL, 1987, 6 (08) : 2381 - 2385
[6] THE E5-ONCOPROTEIN OF BOVINE PAPILLOMAVIRUS IS ORIENTED ASYMMETRICALLY IN GOLGI AND PLASMA-MEMBRANES
BURKHARDT, A
WILLINGHAM, M
GAY, C
JEANG, KT
SCHLEGEL, R
[J]. VIROLOGY, 1989, 170 (01) : 334 - 339
[7] LOCALIZATION OF BOVINE PAPILLOMAVIRUS TYPE-1 E5 PROTEIN TO TRANSFORMED BASAL KERATINOCYTES AND PERMISSIVE DIFFERENTIATED CELLS IN FIBROPAPILLOMA TISSUE
BURNETT, S
JAREBORG, N
DIMAIO, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) : 5665 - 5669
[8] SUCCESSIVE STEPS IN THE PROCESS OF IMMORTALIZATION IDENTIFIED BY TRANSFER OF SEPARATE BOVINE PAPILLOMAVIRUS GENES INTO RAT FIBROBLASTS
CERNI, C
BINETRUY, B
SCHILLER, JT
LOWY, DR
MENEGUZZI, G
CUZIN, F
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) : 3266 - 3270
[9] TRANSFORMING ACTIVITY OF E5A PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE-6 IN NIH-3T3 AND C127 CELLS
CHEN, SL
MOUNTS, P
[J]. JOURNAL OF VIROLOGY, 1990, 64 (07) : 3226 - 3233
[10] TRANSFORMATION-SPECIFIC INTERACTION OF THE BOVINE PAPILLOMAVIRUS E5 ONCOPROTEIN WITH THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TRANSMEMBRANE DOMAIN AND THE EPIDERMAL GROWTH-FACTOR RECEPTOR CYTOPLASMIC DOMAIN
COHEN, BD
GOLDSTEIN, DJ
RUTLEDGE, L
VASS, WC
LOWY, DR
SCHLEGEL, R
SCHILLER, JT
[J]. JOURNAL OF VIROLOGY, 1993, 67 (09) : 5303 - 5311

← 1 2 3 4 5 6 →