IODINE ATOM TRANSFER ADDITION-REACTIONS WITH ALKYNES .2. ALPHA-IODOCARBONYLS

被引：60

作者：

CURRAN, DP ^{[1
]}

KIM, D ^{[1
]}

ZIEGLER, C ^{[1
]}

机构：

[1] AMER CYANAMID CO,LEDERLE LABS,DIV MED RES,PEARL RIVER,NY 10965

来源：

TETRAHEDRON | 1991年 / 47卷 / 32期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(01)86551-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-degrees-Iodo esters, ketones, and nitriles react smoothly in atom transfer addition reactions with alkyl-substituted (nucleophilic) alkynes, but a 3-degrees-iodoester prefers to add to ester-substituted (electrophilic) alkynes. These atom transfer additions are suited for preparing precursors for radical translocation reactions as well for appending beta-lactam side chains.

引用

页码：6189 / 6196

页数：8

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