STEREOSELECTIVE EPOXIDATION OF ASYMMETRIZED 2-ALKENYL-1,3-PROPANEDIOLS

被引：12

作者：

GUANTI, G ^{[1
]}

BANFI, L ^{[1
]}

NARISANO, E ^{[1
]}

THEA, S ^{[1
]}

机构：

[1] CNR,CTR STUDIO DIARILOIDI,GENOA,ITALY

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 47期

关键词：

D O I：

10.1016/0040-4039(91)80450-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetrized 2-alkenyl 1,3-propanediols are stereoselectively epoxidized to the same main diastereoisomer both with 3-chloroperbenzoic acid and the VO(acac)2/t-butyl hydroperoxyde system. Using the latter epoxidating reagent in combination with a protection-deprotection sequence involving the two homoallylic hydroxy groups, all the four cis epoxides were easily achieved in stereoisomeric pure form starting from a single common (Z) precursor.

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页码：6943 / 6946

页数：4

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