TOPOGRAPHY OF THE INHIBITORY AND EXCITATORY RESPONSES TO TRANSCRANIAL MAGNETIC STIMULATION IN A HAND MUSCLE

被引:114
作者
WASSERMANN, EM
PASCUALLEONE, A
VALLSSOLE, J
TORO, C
COHEN, LG
HALLETT, M
机构
来源
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1993年 / 89卷 / 06期
关键词
TRANSCRANIAL MAGNETIC STIMULATION; INHIBITION; MOTOR CORTEX; (HUMAN);
D O I
10.1016/0168-5597(93)90116-7
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We studied the excitatory motor evoked potentials (MEPs) and the inhibitory (silent period) responses to focal transcranial magnetic stimulation (TMS) in the abductor pollicis brevis (APB) of 5 normal subjects to learn whether the scalp topography of the two responses differed. At the scalp location where stimulation produced the highest-amplitude MEP in the voluntarily activated APB, stimulus intensities below the MEP threshold produced silent periods with little or no preceding facilitation. The silent periods had a mean duration of 26.8 +/- 6.8 msec and a mean onset latency of 27.6 +/- 3.6 msec, which was 7.2 +/- 2.3 msec longer than the latency of MEPs produced in the APB by higher stimulus intensities. A period of excitation, with an onset latency of 50-80 msec, often followed the silent period. On averaged trials, a stimulus intensity just above the threshold of the MEP at its optimal position produced MEPs followed by silent periods at a cluster of scalp locations 1 cm apart on the central scalp (medial area) and silent periods with very slight or no preceding facilitation in 3-9 locations lateral to the MEP area (lateral area). This finding was confirmed in 3 subjects with maps constructed from statistical analysis of multiple trials. These maps also showed that MEPs produced from the medial area occurred 4-6 msec earlier than those produced from the lateral area. The integral of the silent period tended to be larger in the lateral area. The motor representation of APB, as defined by TMS, is not homogeneous but rather contains at least two components that differ physiologically and topographically.
引用
收藏
页码:424 / 433
页数:10
相关论文
共 37 条
  • [1] AMASSIAN VE, 1987, J PHYSIOL-LONDON, V394, pP119
  • [2] AMASSIAN VE, 1989, MAGNETIC STIMULATION, P73
  • [3] TOPOGRAPHICAL ORGANIZATION OF CORTICAL EFFERENT ZONES PROJECTING TO DISTAL FORELIMB MUSCLES IN MONKEY
    ASANUMA, H
    ROSEN, I
    [J]. EXPERIMENTAL BRAIN RESEARCH, 1972, 14 (03) : 243 - +
  • [4] PATTERNS OF CONTRACTION OF DISTAL FORELIMB MUSCLES PRODUCED BY INTRACORTICAL STIMULATION IN CATS
    ASANUMA, H
    WARD, JE
    [J]. BRAIN RESEARCH, 1971, 27 (01) : 97 - &
  • [5] TOPOGRAPHIC MAPPING OF THE HUMAN MOTOR CORTEX WITH MAGNETIC STIMULATION - FACTORS AFFECTING ACCURACY AND REPRODUCIBILITY
    BRASILNETO, JP
    MCSHANE, LM
    FUHR, P
    HALLETT, M
    COHEN, LG
    [J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1992, 85 (01): : 9 - 16
  • [6] MOTOR-UNIT RESPONSES IN HUMAN WRIST FLEXOR AND EXTENSOR MUSCLES TO TRANSCRANIAL CORTICAL STIMULI
    CALANCIE, B
    NORDIN, M
    WALLIN, U
    HAGBARTH, KE
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1987, 58 (05) : 1168 - 1185
  • [7] PATTERNS OF FACILITATION AND SUPPRESSION OF ANTAGONIST FORELIMB MUSCLES FROM MOTOR CORTEX SITES IN THE AWAKE MONKEY
    CHENEY, PD
    FETZ, EE
    PALMER, SS
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1985, 53 (03) : 805 - 820
  • [8] EFFECTS OF COIL DESIGN ON DELIVERY OF FOCAL MAGNETIC STIMULATION - TECHNICAL CONSIDERATIONS
    COHEN, LG
    ROTH, BJ
    NILSSON, J
    DANG, N
    PANIZZA, M
    BANDINELLI, S
    FRIAUF, W
    HALLETT, M
    [J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 75 (04): : 350 - 357
  • [9] CORTICAL OUTFLOW TO PROXIMAL ARM MUSCLES IN MAN
    COLEBATCH, JG
    ROTHWELL, JC
    DAY, BL
    THOMPSON, PD
    MARSDEN, CD
    [J]. BRAIN, 1990, 113 : 1843 - 1856
  • [10] DAVEY NJ, 1992, J PHYSIOL-LONDON, V446, pP447