STEREOCHEMISTRY OF ULAPUALIDES, A NEW FAMILY OF TRIS-OXAZOLE-CONTAINING MACROLIDE IONOPHORES FROM MARINE NUDIBRANCHS - A MOLECULAR MECHANICS STUDY

被引：20

作者：

MADDOCK, J ^{[1
]}

PATTENDEN, G ^{[1
]}

WIGHT, PG ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 1993年 / 7卷 / 05期

关键词：

ULAPUALIDES; MARINE IONOPHORES; MOLECULAR MECHANICS STUDY;

D O I：

10.1007/BF00124363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A molecular mechanics study of the marine metabolite ulapualide A, which is suggested to have ionophoric properties, has been carried out on various metal chelated complexes in order to predict the stereochemistry of the natural product. The results suggest a stereochemistry for ulapualide A which is closely similar to structurally related marine metabolites, whose stereochemistries have been established by X-ray crystallography and by partial synthesis.

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页码：573 / 586

页数：14

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