共 21 条
- [21] ZIMMERMANN H, 1994, NEUROSCIENCE, V17, P420
THE MECHANISM OF ATP-INDUCED LONG-TERM POTENTIATION INVOLVES EXTRACELLULAR PHOSPHORYLATION OF MEMBRANE-PROTEINS IN GUINEA-PIG HIPPOCAMPAL CA1 NEURONS
被引：47
作者：
FUJII, S
KATO, H
FURUSE, H
ITO, KI
OSADA, H
HAMAGUCHI, T
KURODA, Y
机构：
[1] RIKEN,INST PHYS & CHEM RES,ANTIBIOT LAB,WAKO,SAITAMA 35101,JAPAN
[2] TOKYO METROPOLITAN INST NEUROSCI,DEPT MOLEC & CELLULAR NEUROBIOL,FUCHU,TOKYO 183,JAPAN
关键词：
ATP;
LONG-TERM POTENTIATION;
ECTOPROTEIN KINASE;
K-252B;
RK682;
D O I：
10.1016/0304-3940(95)11347-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanism of ATP-induced long-term potentiation was studied pharmacologically using guinea-pig hippocampal slices. Application of 1-10 mu M ATP for 10 min transiently depressed and then slowly augmented the synaptic transmission in CA1 neurons leading to long-term potentiation (LTP). This ATP-induced LTP was blocked by the addition of K-252b, an ecto-protein kinase inhibitor, but was enhanced by the addition of RK682, an ecto-phosphatase inhibitor, both of which do not permeate the cell membrane. These results suggest that ATP applied to the perfusate provides enough substrate for ecto-protein kinase to induce LTP through phosphorylation of extracellular domains of membrane proteins in CA1 neurons.
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页码：130 / 132
页数：3
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