ELEVATED HYPOTHALAMIC NOREPINEPHRINE CONTENT IN MICE WITH THE HEREDITARY OBESE-HYPERGLYCEMIC SYNDROME

被引:21
作者
FELDMAN, JM [1 ]
BLALOCK, JA [1 ]
ZERN, RT [1 ]
机构
[1] VET ADM HOSP,DURHAM,NC 27705
关键词
D O I
10.1159/000179052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is evidence that hypothalamic norepinephrine (NE) plays a role in the control of appetite in the rat. Using specific and sensitive radioenzymatic assays, we determined if there was a difference in the tissue (hypothalamus, cerebral cortex and kidney) concentration of NE of of dopamine (DA) in mice with the hereditary obese-hyperglycemic syndrome (ob/ob) and their normal weight littermates. Obese mice had a higher concentration of hypothalamic NE than their normal weight littermates, both when they were in the rapid growth phase (2-3 months of age) and when they were mature (6-7 months of age). The concentration of NE was similar in the cerebral cortex of obese and normal mice and in the kidneys of obese and normal mice. The concentration of DA was similar in the hypothalamus of obese and normal mice and in the cerebral cortex of obese and normal mice. These observations support the concept that alterations in hypothalamic NE may play a role in the obesity of ob/ob mice.
引用
收藏
页码:170 / 178
页数:9
相关论文
共 28 条
[21]  
KOZAK LP, 1971, 43RD JACKS LAB ANN R, P83
[22]   CENTRAL CATECHOLAMINE TURNOVER IN GENETICALLY OBESE MICE (OBOB) [J].
LORDEN, JF ;
OLTMANS, GA ;
MARGULES, DL .
BRAIN RESEARCH, 1976, 117 (02) :357-361
[23]   CENTRAL CATECHOLAMINE LEVELS IN GENETICALLY OBESE MICE (OBOB AND DBDD) [J].
LORDEN, JF ;
OLTMANS, GA ;
MARGULES, DL .
BRAIN RESEARCH, 1975, 96 (02) :390-394
[24]   NORADRENERGIC SYNAPSES FOR SUPRESSION OF FEEDING BEHAVIOR [J].
MARGULES, DL .
LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1969, 8 (13P1) :693-&
[26]  
SAIFER A, 1958, J LAB CLIN MED, V51, P448
[27]  
Westman S, 1968, Diabetologia, V4, P141, DOI 10.1007/BF01219435
[28]  
Zar J.H., 1974, BIOSTATISTICAL ANAL