IMMUNE-COMPLEX P24 ANTIGEN - A NEW PROGNOSTIC MARKER IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

被引：5

作者：

CABEZAS, T ^{[1
]}

QUIROS, E ^{[1
]}

GARCIA, F ^{[1
]}

HERNANDEZQUERO, J ^{[1
]}

BERNAL, MC ^{[1
]}

MARTINEZ, MA ^{[1
]}

DELAHIGUERA, J ^{[1
]}

PIEDROLA, G ^{[1
]}

MAROTO, MC ^{[1
]}

机构：

[1] UNIV GRANADA HOSP,MICROBIOL SERV & INFECT DIS UNIT,E-18071 GRANADA,SPAIN

来源：

INFECTION | 1994年 / 22卷 / 01期

关键词：

D O I：

10.1007/BF01780756

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

p24 antigen (p24 Ag) is usually not found in patients in the asymptomatic phase of HIV infection, mainly because it is bound to anti-p24 antibodies (p24 Ab), with which it forms immune complexes. Nine asymptomatic patients positive for HIV-1 antibodies (stage II CDC criteria) treated with r alpha-interferon were followed (7.5 +/- 0.5 months), and a basal and final sample were tested for p24 Ag immune complexes (p24 Ag-IC), free p24 Ag, p24 Ab, CD4 count, beta 2-microglobulin, properdin B factor, and C3 and C4 complement fractions. p24 Ag-IC was detected in 55.5% of the samples, whereas free p24 Ag was detected in 5.5%. The finding of no change or an increase in p24 Ag-IC serum levels may be considered a prognostic marker. We believe that p24 Ab cannot be used as a prognostic marker unless p24 Ag-IC detection is simultaneously evaluated.

引用

页码：4 / 7

页数：4

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