O-TRIMETHYLSILYLQUINOXALINOL DERIVATIVES OF AROMATIC ALPHA-KETO ACIDS - MASS-SPECTRA AND QUANTITATIVE GAS-CHROMATOGRAPHY

被引：22

作者：

LANGENBECK, U

MENCHHOINOWSKI, A

DIECKMANN, KP

MOHRING, HU

PETERSEN, M

机构：

[1] Institute of Human Genetics, University of Göttingen

来源：

JOURNAL OF CHROMATOGRAPHY | 1978年 / 145卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)81338-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

As an extension of earlier work on aliphatic α-keto acids, a method is described for the quantitative gas chromatographic determination of urinary aromatic α-keto acids. The keto acids are derivatized with o-phenylenediamine to yield the quinoxalinols. These compounds are chromatographed after trimethylsilyation. The aromatic keto acids are stabilized by sodium dithionite (4 mg/ml urine) and storage below 0°. The final derivatives are stable for weeks at room temperature. Low resolution mass spectra are reported. The fragmentation mechanims are elucidated by analysis of O-trimethylsilyl-(TMS)-quinoxalinols, O-(TMS-d9)-quinoxalinols and O-TMS-6(7)-chloroquinoxalinols. © 1978.

引用

页码：185 / 193

页数：9

共 29 条

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