POTENTIATION OF ANGIOTENSIN-II-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS, CALCIUM MOBILIZATION AND CONTRACTION OF RENAL MESANGIAL CELLS UPON DOWN-REGULATION OF PROTEIN KINASE-C

被引：38

作者：

PFEILSCHIFTER, J

FANDREY, J

OCHSNER, M

WHITEBREAD, S

DEGASPARO, M

机构：

[1] CIBA GEIGY AG,CENT FUNCT RES,CH-4002 BASEL,SWITZERLAND

[2] MED UNIV LUBEK,INST PHYSIOL,W-2400 LUBECK,GERMANY

来源：

FEBS LETTERS | 1990年 / 261卷 / 02期

关键词：

Angiotensin II; Ca[!sup]2+[!/sup; Contraction; Mesangial cell; Phosphoinositide; Protein kinase C;

D O I：

10.1016/0014-5793(90)80578-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-term pretreatment of rat mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulated protein kinase C activity and potentiated the angiotensin II-induced inositol trisphosphate (InsP3) formation. This increased response to angiotensin II occurred without a significant change in the receptor number or Kd value of angiotensin II binding to the cells. The biologically inactive phorbol ester 4α-phorbol 12,13-di-decanoate was without effect on angiotensin II-stimulated InsP3 generation. Long-term pretreatment with TPA also increased the angiotensin II-induced mobilization of Ca2+ and the subsequent contraction of mesangial cells. © 1990.

引用

页码：307 / 311

页数：5

共 31 条

[21] TUMOR PROMOTOR 12-O-TETRADECANOYLPHORBOL 13-ACETATE INHIBITS ANGIOTENSIN-II-INDUCED INOSITOL PHOSPHATE PRODUCTION AND CYTOSOLIC CA-2+ RISE IN RAT RENAL MESANGIAL CELLS [J].