VIRULENCE PROPERTIES OF ERYSIPELAS-ASSOCIATED GROUP-A STREPTOCOCCI

被引:19
作者
NORRBY, A [1 ]
ERIKSSON, B [1 ]
NORGREN, M [1 ]
RONSTROM, CJ [1 ]
SJOBLOM, AC [1 ]
KARKKONEN, K [1 ]
HOLM, SE [1 ]
机构
[1] ROSLAGSTULL HOSP,DEPT INFECT DIS,S-11489 STOCKHOLM,SWEDEN
关键词
D O I
10.1007/BF01961132
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Group A streptococcal isolates (n = 53) recovered from 38 erysipelas patients in 1988 and 1990 in Sweden were analysed with respect to serotype, erythrogenic toxin production and polymorphism in the emm gene region. Serotype determination showed a dominance of type T1M1 (28.6 % of the strains), but T type 8 was also prevalent (14.3 %). In the majority of the strains only a low production of erythrogenic toxin A was demonstrated, while both toxin B and C production were high. Polymorphism was detected in the emm gene region of T1M1 strains at a frequency of 64 %. These erysipelas associated group A streptococci were more heterogenic with respect to serotype distribution and polymorphism in the emm gene region compared to previously studied group A streptococci isolated during an outbreak of serious streptococcal infections in Sweden in 1988/1989. The material included isolates from two cases of recurrence, and typing of the isolates indicated that the patients had been infected by the same serotype as in the primary infection.
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收藏
页码:1136 / 1143
页数:8
相关论文
共 26 条
[11]   MOLECULAR ANALYSIS OF PYROGENIC EXOTOXINS FROM STREPTOCOCCUS-PYOGENES ISOLATES ASSOCIATED WITH TOXIC SHOCK-LIKE SYNDROME [J].
HAUSER, AR ;
STEVENS, DL ;
KAPLAN, EL ;
SCHLIEVERT, PM .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (08) :1562-1567
[12]  
HOLLINGSHEAD SK, 1986, J BIOL CHEM, V261, P1677
[13]   ASPECTS OF PATHOGENESIS OF SERIOUS GROUP-A STREPTOCOCCAL INFECTIONS IN SWEDEN, 1988-1989 [J].
HOLM, SE ;
NORRBY, A ;
BERGHOLM, AM ;
NORGREN, M .
JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (01) :31-37
[14]  
HOLM SE, 1967, ACTA PATHOL MIC SC, V69, P264
[15]   ERYSIPELAS AND GROUP-G STREPTOCOCCI [J].
HUGOPERSSON, M ;
NORLIN, K .
INFECTION, 1987, 15 (03) :184-187
[16]  
LANCEFIELD RC, 1962, J IMMUNOL, V89, P307
[17]  
MAXTED WR, 1972, STREPTOCOCCI STREPTO, P256
[18]   STREPTOCOCCUS-PYOGENES CAUSING TOXIC-SHOCK-LIKE SYNDROME AND OTHER INVASIVE DISEASES - CLONAL DIVERSITY AND PYROGENIC EXOTOXIN EXPRESSION [J].
MUSSER, JM ;
HAUSER, AR ;
KIM, MH ;
SCHLIEVERT, PM ;
NELSON, K ;
SELANDER, RK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2668-2672
[19]   GENETIC DIVERSITY IN T1M1 GROUP-A STREPTOCOCCI IN RELATION TO CLINICAL OUTCOME OF INFECTION [J].
NORGREN, M ;
NORRBY, A ;
HOLM, SE .
JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (05) :1014-1020
[20]  
PICHICHERO ME, 1991, PEDIAT INFECT DIS S, V10, P50