NOVEL ACTIONS OF INHIBITORS OF DNA TOPOISOMERASE-II IN DRUG-RESISTANT TUMOR-CELLS

被引：20

作者：

BECK, WT ^{[1
]}

KIM, R ^{[1
]}

CHEN, M ^{[1
]}

机构：

[1] UNIV TENNESSEE, COLL MED, DEPT PHARMACOL, MEMPHIS, TN 38163 USA

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1994年 / 34卷

关键词：

TOPOISOMERASE II INHIBITORS; DNA-PROTEIN COMPLEXES; MULTIDRUG RESISTANCE;

D O I：

10.1007/BF00684858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We review herein current work on the cytotoxic and cellular actions of two classes of inhibitors of DNA topoisomerase II: one represented by etoposide and teniposide, which stabilize DNA-protein complexes, and another represented by merbarone and aclarubicin, which do not stabilize such complexes. We discuss current concepts of protooncogene activation and cell cycle perturbations by some of these inhibitors and summarize recent findings of novel actions of the latter compounds in tumor cells that express a mutant topoisomerase II.

引用

页码：S14 / S18

页数：5