CAPILLARY-TISSUE ARRANGEMENT IN THE SKELETAL-MUSCLE OPTIMIZED FOR OXYGEN-TRANSPORT IN ALL MAMMALS

被引：10

作者：

BABA, K

KAWAMURA, T

SHIBATA, M

SOHIRAD, M

KAMIYA, A

机构：

[1] Institute of Medical Electronics, University of Tokyo, Tokyo

来源：

MICROVASCULAR RESEARCH | 1995年 / 49卷 / 02期

关键词：

D O I：

10.1006/mvre.1995.1013

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aim of this computer simulation study is to evaluate the efficiency of capillary networks in the skeletal muscle for oxygen (O-2) delivery to tissue for all mammals. This was performed by: (1) employing Krogh's cylinder model for the capillary-tissue system and the minimum volume model for the vascular system, (2) allometrically assessing the muscle blood how and O-2 consumption rate (the main input data) in the resting and exercising states as power functions of body weight from the data reported for several mammals, and (3) calculating the cost-performance of the system from the ratio (maximum O-2 uptake of tissue)/(minimum energy expenditure of blood Row supply), as a function of number of capillaries. The results obtained for body weights ranging from 100 g to 1000 kg revealed that for each body weight and metabolic state, the efficiency curve attains a peak at a specific optimum capillary number, and that the calculated values of total muscle mass, capillary density, and capillary Bow-rate by using the optimum capillary number and tissue radius during exercise agree remarkably well with those actually measured in various animals. These findings suggest the validity of a working hypothesis that in all mammals, the capillary arrangement in the skeletal muscle is optimized for O-2 delivery to tissue during exercise. (C) 1995 Academic Press, Inc.

引用

页码：163 / 179

页数：17

共 59 条

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