COPPER(II) COMPLEXES OF (1-[ISOPROPYLAMINE]-3-[1-NAPHTHYLOXY]-2-PROPANOL) (PROPRANOLOL)

被引：21

作者：

BONTCHEV, PR ^{[1
]}

KADUM, H ^{[1
]}

EVTIMOVA, B ^{[1
]}

NACHEV, C ^{[1
]}

ZHECHEVA, E ^{[1
]}

MEHANDJIEV, D ^{[1
]}

IVANOV, D ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,INST INORGAN CHEM,BU-1113 SOFIA,BULGARIA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 48卷 / 02期

关键词：

D O I：

10.1016/0162-0134(92)80024-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complexation between copper(II) and the anti-hypertension drug propranolol (HL) was studied both in methanol and slightly alkaline aqueous media at M:HL = 1:2, and 1:4, respectively. Copper(II) forms two types of complexes-a violet one, CuL2.2HL with mono- and bifunctionally bonded ligands, and a green one, of dimeric type, Cu2L2Cl2 with propranolol, coordinated through its nitrogen and oxygen atoms with alkoxide bridges. The content and structure of the complexes were studied using UV-VIS, IR and EPR spectra, and magnetochemical and elemental analysis data. The stability constants beta1 and beta2 of the complexes CuL+ and CuL2 were determined in 50% methanol.

引用

页码：153 / 161

页数：9

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