NUCLEAR-MAGNETIC-RESONANCE STUDIES OF N-H BONDS IN PLATINUM ANTICANCER COMPLEXES - DETECTION OF REACTION INTERMEDIATES AND HYDROGEN-BONDING IN GUANOSINE 5'-MONOPHOSPHATE ADDUCTS OF CIS-[PTCL2(NH3)2]

被引：39

作者：

BERNERSPRICE, SJ

FRENKIEL, TA

RANFORD, JD

SADLER, PJ

机构：

[1] UNIV LONDON, BIRKBECK COLL,DEPT CHEM, GORDON HOUSE & CHRISTOPHER INGOLD LAB, 29 GORDON SQ, LONDON WC1H 0PP, ENGLAND

[2] GRIFFITH UNIV, DIV SCI & TECHNOL, NATHAN, QLD 4111, AUSTRALIA

[3] NATL INST MED RES, CTR BIOMED, LONDON NW7 1AA, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1992年 / 13期

关键词：

D O I：

10.1039/dt9920002137

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions between N-15-labelled cis-[PtCl2(NH3)2] and guanosine 5'-monophosphate (GMP) have been studied in aqueous solutions at millimolar concentrations using N-15-edited one-dimensional H-1 NMR spectroscopy, and two-dimensional H-1,N-15] heteronuclear multiple quantum coherence NMR spectroscopy; the reactive species [PtCl(H2O)(NH3)2]+ was detected, as well as hydrogen bonding in the product [Pt(GMP-N7)2(NH3)2]2+.

引用

页码：2137 / 2139

页数：3

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