KILLING OF TRYPANOSOMES BY THE HUMAN HAPTOGLOBIN-RELATED PROTEIN

被引：148

作者：

SMITH, AB ^{[1
]}

ESKO, JD ^{[1
]}

HAJDUK, SL ^{[1
]}

机构：

[1] UNIV ALABAMA, SCH MED & DENT, DEPT BIOCHEM & MOLEC GENET, BIRMINGHAM, AL 35294 USA

来源：

SCIENCE | 1995年 / 268卷 / 5208期

关键词：

D O I：

10.1126/science.7716520

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

African trypanosomes cause disease in humans and animals. Trypanosoma brucei brucei affects cattle but not humans because of its sensitivity to a subclass of human high density lipoproteins (HDLs) called trypanosome lytic factor (TLF). TLF contains two apolipoproteins that are sufficient to cause lysis of T. b. brucei in vitro. These proteins were identified as the human haptoglobin-related protein and paraoxonase-arylesterase. An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity.

引用

页码：284 / 286

页数：3