CIRCULAR-DICHROISM STUDIES OF THE SELF-ASSOCIATION OF AMPHOTERICIN-B

被引：18

作者：

BRITTAIN, HG ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB,PHARMACEUT RES INST,NEW BRUNSWICK,NJ 08903

来源：

CHIRALITY | 1994年 / 6卷 / 08期

关键词：

CIRCULAR DICHROISM; AMPHOTERICIN B; SELF-ASSOCIATION; MANOMER OLIGOMER; SOLVENT EFFECTS;

D O I：

10.1002/chir.530060811

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Circular dichroism (CD) spectroscopy has been used to evaluate the ability of 21 different solvents to influence the aggregation state of amphotericin B. Using the relative donor/acceptor tendencies known for each solvent system, it was possible to deduce information as to the factors which goven the self-association of amphotericin B. It was concluded that in the absence of strong solvent interaction, amphotericin B prefers to self-associate into oligomeric species. This intrinsic driving force can be overcome through the use of solvents which function as strong electron pair donors, probably forming specific solvent-solute species. (C) 1994 Wiley-Liss, Inc.

引用

页码：665 / 669

页数：5