CREATINE-KINASE IN SERUM AFTER GRAND MAL SEIZURES

被引:17
作者
GLOTZNER, FL [1 ]
PLANNER, M [1 ]
GAAB, M [1 ]
机构
[1] UNIV WURZBURG,DEPT NEUROSURG,D-8700 WURZBURG,FED REP GER
关键词
Creatine kinase; Generalized seizures; Grand mal;
D O I
10.1159/000115112
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Total creatine kinase (CK) activity in serum was increased post-ictally in 14 out of 17 patients (82%) admitted to the hospital after one or more generalized seizures. No correlation was found between increased CK levels and cerebral or extracerebral ictal injuries. A highly significant negative correlation exists between regular anti-epileptic treatment and elevated levels of the enzyme (p < 0.01). The maximum value of CK activity was found on the 3rd or 4th post-ictal day in 10 out of 14 patients. Correspondingly, late CK-activity increases on the 2nd–4th post-ictal day were found in 6 out of 9 experiments with unrestrained cats. In cats immobilized by relaxant drugs, only an initial rise of the enzyme within 24 h after the electrographic seizures was observed. These findings suggest that sources other than the skeletal muscle alone contribute to the increased CK activity after grand mal seizures. © 1979 S. Karger AG, Basel.
引用
收藏
页码:399 / 404
页数:6
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