RAPID AND ACCURATE STABILITY-INDICATING ASSAY FOR NITROGLYCERIN

A rapid high‐pressure liquid chromatographic method for determining the nitroglycerin concentration in liquid dosage forms and intravenous admixture solutions is presented. A coefficient of variation of less than 1.8% was achieved over the concentration range most commonly encountered (50–500 μg/ml). A variable wavelength detector (λ = 218 nm) and a micro‐alkyl phenyl column were employed. The mobile phase was acetonitrile‐tetrahydrofuran water (26:10:64). Total analysis time was 12 min. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company