A CONVENIENT METHOD FOR THE SYNTHESIS OF N2,N2-DIMETHYLGUANOSINE BY REDUCTIVE C-S BOND-CLEAVAGE WITH TRIBUTYLTIN HYDRIDE

被引：15

作者：

SEKINE, M

SATOH, T

机构：

[1] Department of Life Science, Faculty of Science, Tokyo Institute of Technology, Nagatsuta, Midoriku

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 03期

关键词：

D O I：

10.1021/jo00003a052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the N-methylation of guanosine is described. The 1,3-benzodithiol-2-yl group was introduced into the 2-amino group of 2',3',5'-tri-O-acetylguanosine (3) and then converted into a methyl group by reductive C-S bond cleavage with tributyltin hydride. This method was also applied to the synthesis of N2,N2-dimethylguanosine. A similar reductive conversion of a (p-tolylthio)methyl group into a methyl group was studied.

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页码：1224 / 1227

页数：4

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