CHRONIC INTRATHECAL CANNULATION AFFECTS HYPOTHALAMIC OPIOIDS DEPENDING ON THE TECHNIQUE EMPLOYED

被引：3

作者：

DIB, B ^{[1
]}

SACERDOTE, P ^{[1
]}

PANERAI, AE ^{[1
]}

机构：

[1] UNIV MILAN, SCH MED, DEPT PHARMACOL, I-20129 MILAN, ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 40卷 / 02期

关键词：

BETA-ENDORPHIN; MET-ENKEPHALIN; CHRONIC CANNULATION; INTRATHECAL; INTRAPERITONEAL;

D O I：

10.1016/0091-3057(91)90578-P

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous studies have shown that chronic intrathecal cannulation can interfere with the homeostasis of central opioid peptides. These results show that beta-endorphin and Met-enkephalin concentrations did not change in the hypothalamus of rats bearing a chronic cannula inserted between C8-T1 up to L3 and fixed to the processus transversus T1. These results that chronically cannulated rats can be considered as normal when studying hypothalamic beta-endorphin or Met-enkephalin concentrations, and used in physiological studies, depending on the technique employed.

引用

页码：449 / 451

页数：3

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