IS EXTRAPITUITARY ACTION OF GONADOTROPIN-RELEASING-HORMONE BIOLOGICALLY SIGNIFICANT

被引：20

作者：

IMAI, A

FURUI, T

TAMAYA, T

机构：

[1] Department of Obstetrics and Gynecology, Gifu University School of Medicine, Tsukasamachi

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1992年 / 29卷

关键词：

OVARIAN FUNCTION; HORMONE-SECRETORY TUMORS;

D O I：

10.1177/000456329202900501

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Gonadotrophin-releasing hormone (Gn-RH) mediates the hypothalamic control of pituitary gonadotrophin (Gn) secretion. During the last decade, evidence has accumulated to suggest that Gn-RH and its agonists can exert extrapituitary effects via specific tissue receptors which have been identified in many tissues such as the ovary and certain hormone-sensitive tumours.1,2 The stimulation of Gn-RH receptor suppresses Gn-dependent maturation and steroidogenesis in the ovary, and expresses the antigrowth signal in the tumours. In contrast to a correlation between the direct extrapituitary effects of Gn-RH and the presence of Gn-RH binding sites in the cells, the physiological role of the extrapituitary Gn-RH receptor is not clear.

引用

页码：477 / 480

页数：4

共 51 条

[41] INHIBITION OF GROWTH OF HUMAN MAMMARY-TUMOR CELLS BY POTENT ANTAGONISTS OF LUTEINIZING-HORMONE-RELEASING HORMONE [J].