EFFECTS OF ADDITIVES IN THE REDUCTION USING BAKERS-YEAST CELL-FREE-EXTRACT

被引：5

作者：

ISHIHARA, K ^{[1
]}

HIGASHI, Y ^{[1
]}

TSUBOI, S ^{[1
]}

UTAKA, M ^{[1
]}

机构：

[1] OKAYAMA UNIV, FAC ENGN, DEPT APPL CHEM, TSUSHIMA, OKAYAMA 700, JAPAN

来源：

CHEMISTRY LETTERS | 1995年 / 04期

关键词：

D O I：

10.1246/cl.1995.253

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By addition of diisopropyl fluorophosphate the undesirable hydrolysis of alpha-acetoxy ketones or alcohols was completely inhibited in the asymmetric reduction using bakers' yeast cell-free extract, but hardly inhibited in the reduction using the whole cell suspension. The control of stereoselectivity by addition of metal chlorides was also conducted more effectively in the cell-free extract.

引用

页码：253 / 254

页数：2

共 9 条

[1] BAKERS-YEAST MEDIATED TRANSFORMATIONS IN ORGANIC-CHEMISTRY [J].

CSUK, R ;

GLANZER, BI .

CHEMICAL REVIEWS, 1991, 91 (01) :49-97

[2] HIGHLY EFFICIENT ENZYMATIC ASYMMETRIC REDUCTION BY USE OF REGENERATION NADPH IN BAKERS-YEAST CELL-FREE-EXTRACT [J].

ISHIHARA, K ;

SAKAI, T ;

TSUBOI, S ;

UTAKA, M .

TETRAHEDRON LETTERS, 1994, 35 (26) :4569-4570

[3] STEREOCHEMICAL CONTROL OF BAKERS-YEAST MEDIATED REDUCTION OF A PROTECTED 2-HYDROXY KETONE [J].

MANZOCCHI, A ;

FIECCHI, A ;

SANTANIELLO, E .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (18) :4405-4407

[4] STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTION .8. STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTION OF BETA-KETO-ESTERS [J].

NAKAMURA, K ;

KAWAI, Y ;

OKA, S ;

OHNO, A .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1989, 62 (03) :875-879

[5] A NEW METHOD FOR STEREOCHEMICAL CONTROL OF MICROBIAL REDUCTION - REDUCTION OF BETA-KETO-ESTERS WITH BAKERS-YEAST IMMOBILIZED BY MAGNESIUM ALGINATE [J].

NAKAMURA, K ;

KAWAI, Y ;

OKA, S ;

OHNO, A .

TETRAHEDRON LETTERS, 1989, 30 (17) :2245-2246

[6]

NAKAMURA K, 1989, CHEM LETT, P875

[7]

POPPE L, 1992, SELECTIVE BIOCATALYS, pCH5

[8]

SERVI S, 1990, SYNTHESIS-STUTTGART, P1

[9]

UTAKA M, 1991, J SYNTH ORG CHEM JPN, V50, P647

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