DEVELOPMENT AND APPLICATIONS OF A MOLECULAR GENETIC-LINKAGE MAP OF THE MOUSE GENOME

被引：540

作者：

COPELAND, NG

JENKINS, NA

机构：

[1] Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 04期

关键词：

D O I：

10.1016/0168-9525(91)90455-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interspecific mouse backcrosses provide almost limitless genetic variation for gene mapping. We have used interspecific backcrosses to develop the first comprehensive molecular genetic linkage map of the mouse genome. More than 600 loci have been positioned on the map; the current average map resolution is less than 3 cM. Since all loci were mapped using a single backcross panel, gene order can be determined unambiguously. With this level of resolution, it is now possible to position any new locus on the linkage map with virtually 100% certainty. In this article, we review how interspecific linkage maps are constructed, the salient features of our linkage map, and some of the many applications of interspecific linkage maps, in general, for future research.

引用

页码：113 / 118

页数：6

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