INVITRO EFFECTS OF N-NITROSOATRAZINE ON CHROMOSOME BREAKAGE

被引：30

作者：

MEISNER, LF ^{[1
]}

ROLOFF, BD ^{[1
]}

BELLUCK, DA ^{[1
]}

机构：

[1] RISK WRITERS LTD,MINNEAPOLIS,MN 55406

来源：

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 1993年 / 24卷 / 01期

关键词：

D O I：

10.1007/BF01061097

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Exposing human lymphocyte cultures to concentrations of N-nitrosoatrazine (NNAT) as low as 0.0001 mug/ml results in significant elevations in chromosome breakage as well as an increased mitotic index. In contrast, 1,000-10,000-fold greater concentrations of nitrates, nitrites, and/or atrazine was required to produce comparable chromosome damage and, in those cases where the mitotic index was affected, it was decreased. Simultaneous administration of nitrates or nitrites with atrazine caused less chromosome damage than low concentrations of NNAT without affecting the mitotic index, illustrating that metabolic conversion of contaminants with minimal genotoxicity can give rise to compounds such as NNAT which are even more genotoxic.

引用

页码：108 / 112

页数：5