PSEUDO-PROLINES IN PEPTIDE-SYNTHESIS - DIRECT INSERTION OF SERINE AND THREONINE DERIVED OXAZOLIDINES IN DIPEPTIDES

被引：65

作者：

WOHR, T ^{[1
]}

MUTTER, M ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST ORGAN CHEM,DORIGNY BCH,CH-1015 LAUSANNE,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 22期

关键词：

D O I：

10.1016/0040-4039(95)00667-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dipeptides containing serine and threonine derived oxazolidines are prepared by reacting side chain unprotected dipeptides containing C-terminal Thr or Ser with dimethoxypropane. The resulting building blocks can be coupled in Fmoc-based solid phase peptide synthesis enhancing peptide solvation by its secondary structure disrupting potential. The present procedure may be considered as a first step towards a reversible modification of structural and functional properties of bioactive peptides and proteins.

引用

页码：3847 / 3848

页数：2

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