CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN BETA-1-ADRENERGIC RECEPTOR 5'-FLANKING PROMOTER REGION

被引：63

作者：

COLLINS, S

OSTROWSKI, J

LEFKOWITZ, RJ

机构：

[1] DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 1-2期

关键词：

BETA-1-ADRENERGIC RECEPTOR GENE; TRANSCRIPTION REGULATION; PCR SEQUENCING;

D O I：

10.1016/0167-4781(93)90287-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present 3.1 kb of the nucleotide sequence from the 5'-flanking region of the human beta1-adrenergic receptor gene. The first 1.0 kb upstream from the translational start site is composed of 72% G + C residues. The sequence was analyzed for the presence of transcriptional regulatory elements and contains putative thyroid hormone, glucocorticoid hormone and cAMP response elements. These putative hormone response elements support physiological evidence that thyroid and glucocorticoid hormones regulate beta1AR function by affecting receptor expression in tissues such as heart and adipose, where beta1-adrenergic receptors are important regulators of heart rate and lipolysis, respectively.

引用

页码：171 / 174

页数：4

共 23 条

[11] DOWN-REGULATION OF BETA-ADRENERGIC RECEPTORS - AGONIST-INDUCED REDUCTION IN RECEPTOR MESSENGER-RNA LEVELS [J].