CHARACTERIZATION OF A BORNA-DISEASE VIRUS GLYCOPROTEIN, GP18

被引：50

作者：

KLICHE, S

BRIESE, T

HENSCHEN, AH

STITZ, L

LIPKIN, WI

机构：

[1] UNIV CALIF IRVINE, DEPT NEUROL, NEUROVIROL LAB, IRVINE, CA 92717 USA

[2] UNIV CALIF IRVINE, DEPT MOLEC BIOL & BIOCHEM, IRVINE, CA 92717 USA

[3] FREE UNIV BERLIN, INST VIROL, D-13353 BERLIN, GERMANY

[4] UNIV GIESSEN, INST VIROL, D-35392 GIESSEN, GERMANY

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 11期

关键词：

D O I：

10.1128/JVI.68.11.6918-6923.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Borna disease virus is a nonsegmented negative-strand RNA virus that causes neurologic disease in a wide variety of animal hosts. Here we describe identification and characterization of the first glycoprotein in this viral system. The 18-kDa glycoprotein, gp18, has been purified from infected rat brain. Isolation and micro-sequencing of this protein allowed identification of a 16.2-kDa open reading frame in the viral antigenome. Lectin binding and endoglycosidase sensitivity assays indicate that gp18 is an unusual N-linked glycoprotein.

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页码：6918 / 6923

页数：6

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