A GENE THAT ENCODES A PROTEIN CONSISTING SOLELY OF ZINC FINGER DOMAINS IS PREFERENTIALLY EXPRESSED IN TRANSFORMED MOUSE CELLS

被引：25

作者：

ERNOULTLANGE, M ^{[1
]}

KRESS, M ^{[1
]}

HAMER, D ^{[1
]}

机构：

[1] INST RECH SCI CANC,UNITE ONCOL MOLEC,F-94802 VILLEJUIF,FRANCE

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 01期

关键词：

D O I：

10.1128/MCB.10.1.418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the cloning and characterization of the mouse MOK-2 gene, a new member of the Kruppel family of zinc finger proteins. Sequencing of both cDNA and genomic clones showed that the predicted MOK-2 protein consists of seven zinc finger domains with only five additional amino acids. The finger domains of MOK-2 are highly homologous to one another but not to those of other zinc finger proteins. MOK-2 is preferentially expressed in transformed cell lines, brain tissue, and testis tissue. Its possible role in cellular transformation is discussed.

引用

页码：418 / 421

页数：4

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