SYNTHESIS OF (R)-3-BENZYL-3-METHYL-2-AZETIDINONE AND (S)-3-BENZYL-3-METHYL-2-AZETIDINONE IN ENANTIOMERICALLY PURE FORM

被引:6
作者
CATIVIELA, C
DIAZDEVILLEGAS, MD
GALVEZ, JA
机构
[1] Instituto de Ciencia de Materiales de Aragón, Departamento de Quimica Orgánica, Universidad de Zaragoza-C.S.I.C.
关键词
D O I
10.1016/S0957-4166(00)82097-2
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The diastereoselective methylation of the enolate of 10-dicyclohexylsulfamoylisobornyl-3-phenyl-2-cyanopropanoate is reported. This methylation was carried out under a variety of conditions to achieve a good yield and selectivity and the reaction product was reduced and cyclised to the corresponding beta-lactam in high yield.
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页码:1141 / 1144
页数:4
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