INFLUENCE OF THE PREPARATION METHOD OF SOLID DISPERSIONS ON THEIR DISSOLUTION RATE - STUDY OF TRIAMTERENE-D-MANNITOL SYSTEM

被引:38
作者
ARIAS, MJ
GINES, JM
MOYANO, JR
PEREZMARTINEZ, JI
RABASCO, AM
机构
[1] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville
关键词
DISSOLUTION RATE; D-MANNITOL; DSC; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION; SPRAY-DRYING; TRIAMTERENE; X-RAY DIFFRACTION;
D O I
10.1016/0378-5173(95)00026-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this paper, we illustrate the usefulness of spray-drying as a resourceful procedure for preparing solid dispersions. The study in the solid state of the triamterene-D-mannitol system from 10 to 40% w/w drug included scanning electron microscopy (SEM), X-ray diffraction (DRX) and differential scanning calorimetry (DSC). The main finding arising from the former studies was that a strong drug-carrier interaction existed in the systems prepared by spray-drying. In contrast, solid dispersions prepared by the melting carrier method showed only weak interactions between triamterene and D-mannitol. This observation helps to explain the much better dissolution rates obtained for the spray-dried outputs.
引用
收藏
页码:25 / 31
页数:7
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