STUDIES ON THE HYDROGENATION OF 6-(HYDROXYMETHYL)PYRIDINE-2-CARBOXYLATES AND ITS APPLICATION TO THE SYNTHESIS OF 6-(HYDROXYMETHYL)PIPERIDINE-2-CARBOXYLIC ACID-DERIVATIVES

被引：3

作者：

BOLOS, J

GUBERT, S

ANGLADA, L

PEREZ, A

SACRISTAN, A

ORTIZ, JA

机构：

[1] Medicinal Chemistry Department, Centro de Investigación Grupo Ferrer, Barcelona, 08028, Juan de Sada

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310635

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the novel amino acid 6-(hydroxymethyl)-2-piperidinecarboxylic acid (1a) and its ethyl ester 1b is reported. In the hydrogenation of 6-(hydroxymethyl)pyridine-2-carboxylates, hydrogenolysis of the alcohol group appeared as an unusual side reaction. Optimization of the reaction conditions allowed us to minimize hydrogenolysis and afforded pure 1.

引用

页码：1493 / 1496

页数：4

共 10 条

[1]

BARCZYNSKI P, 1974, ROCZ CHEM, V48, P903

[2]

DAY AR, 1968, Patent No. 3388128

[3] A NEW AND DIASTEREOSELECTIVE SYNTHESIS OF THREO-ARYL-2-PIPERIDYLMETHANOL DERIVATIVES [J].