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EARLY DAMAGE INDICATORS IN THE LUNG .3. BIOCHEMICAL AND CYTOLOGICAL RESPONSE OF THE LUNG TO INHALED METAL-SALTS
被引:128
作者
:
HENDERSON, RF
论文数:
0
引用数:
0
h-index:
0
机构:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque
HENDERSON, RF
REBAR, AH
论文数:
0
引用数:
0
h-index:
0
机构:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque
REBAR, AH
PICKRELL, JA
论文数:
0
引用数:
0
h-index:
0
机构:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque
PICKRELL, JA
NEWTON, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque
NEWTON, GJ
机构
:
[1]
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque
来源
:
TOXICOLOGY AND APPLIED PHARMACOLOGY
|
1979年
/ 50卷
/ 01期
关键词
:
D O I
:
10.1016/0041-008X(79)90500-3
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
The validity of using the enzymatic and cytologic profile of airway fluids to indicate lung damage was tested in animals exposed by inhalation to either a known toxic metallic salt (CdCl2) or a relatively innocuous salt (CrCl3). The enzymatic and cytologic response of the airways was compared to histopathological evaluation of lung damage. Syrian hamsters were exposed to an aerosol of CdCl2 (aerodynamic diameter = 1.7 μm, σg {reversed tilde equals} 1.7) to achieve an initial lung burden (ILB) of 0.6 ± 0.3 and 4.4 ± 1.2 μg of CdCl2 or to an aerosol of CrCl3 (count median diameter = 1.2 μm, σg {reversed tilde equals} 1.5) to achieve an ILB of 0.7 ± 0.2 or 20 ± 10 μg of CrCl3. Animals were sacrificed at 2 hr, 1, 7, and 21 days after exposure. A sample of airay fluid was obtained by bronchopulmonary lavage and examined for the enzymatic profile of the cell-free fraction and the cytological profile of the cell fraction. Lung tissue enzyme activities were also measured and histopathologic evaluations were made on lung tissue from exposed, but nonlavaged, animals. In the lavage fluid from animals exposed to CdCl2, the enzymatic and cytologic data demonstrated a dose-response pattern and the airway response preceded enzymatic changes in the lung tissue. Tissue morphological changes correlated well with the biochemical changes. The response of the lung to CrCl3 was minimal by both morphological and biochemical evaluations. Airway enzymatic and cytologic responses were shown to be potentially useful as indicators of lung damage in toxicological screening programs. © 1979.
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收藏
页码:123 / 136
页数:14
相关论文
共 27 条
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UNANUE ER, 1976, AM J PATHOL, V83, P395
[22]
PULMONARY HISTIOCYTOSIS SIMULATING DESQUAMATIVE INTERSTITIAL PNEUMONIA IN RATS RECEIVING ORAL IPRINDOLE
VIJEYARATNAM, GS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CEYLON, DEPT PATHOL, COLOMBO, Ceylon, SRI LANKA
VIJEYARATNAM, GS
CORRIN, B
论文数:
0
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0
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0
机构:
UNIV CEYLON, DEPT PATHOL, COLOMBO, Ceylon, SRI LANKA
CORRIN, B
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JOURNAL OF PATHOLOGY,
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METAL TOXICITY FOR RABBIT ALVEOLAR MACROPHAGES INVITRO
WATERS, MD
论文数:
0
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0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
WATERS, MD
GARDNER, DE
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0
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0
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0
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ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
GARDNER, DE
ARANYI, C
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0
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0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
ARANYI, C
COFFIN, DL
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0
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ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
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ENVIRONMENTAL RESEARCH,
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EFFECT OF CYCLIC AMP ON RELEASE OF LYSOSOMAL ENZYMES FROM PHAGOCYTES
WEISSMAN.G
论文数:
0
引用数:
0
h-index:
0
WEISSMAN.G
DUKOR, P
论文数:
0
引用数:
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DUKOR, P
ZURIER, RB
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ZURIER, RB
[J].
NATURE-NEW BIOLOGY,
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PROLIFERATION OF TYPE-2 ALVEOLAR CELLS - REVIEW OF COMMON RESPONSES IN TOXIC LUNG INJURY
WITSCHI, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL,QUEBEC,CANADA
UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL,QUEBEC,CANADA
WITSCHI, H
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TOXICOLOGY,
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1978, CRITERIA DOSE EFFECT
[27]
1974, CHROMIUM
←
1
2
3
→
共 27 条
[21]
UNANUE ER, 1976, AM J PATHOL, V83, P395
[22]
PULMONARY HISTIOCYTOSIS SIMULATING DESQUAMATIVE INTERSTITIAL PNEUMONIA IN RATS RECEIVING ORAL IPRINDOLE
VIJEYARATNAM, GS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CEYLON, DEPT PATHOL, COLOMBO, Ceylon, SRI LANKA
VIJEYARATNAM, GS
CORRIN, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CEYLON, DEPT PATHOL, COLOMBO, Ceylon, SRI LANKA
CORRIN, B
[J].
JOURNAL OF PATHOLOGY,
1972,
108
(02)
: 105
-
+
[23]
METAL TOXICITY FOR RABBIT ALVEOLAR MACROPHAGES INVITRO
WATERS, MD
论文数:
0
引用数:
0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
WATERS, MD
GARDNER, DE
论文数:
0
引用数:
0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
GARDNER, DE
ARANYI, C
论文数:
0
引用数:
0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
ARANYI, C
COFFIN, DL
论文数:
0
引用数:
0
h-index:
0
机构:
ENVIRONM PROTECTION AGCY,NATL ENVIRONM RES CTR,RES TRIANGLE PK,NC 27711
COFFIN, DL
[J].
ENVIRONMENTAL RESEARCH,
1975,
9
(01)
: 32
-
47
[24]
EFFECT OF CYCLIC AMP ON RELEASE OF LYSOSOMAL ENZYMES FROM PHAGOCYTES
WEISSMAN.G
论文数:
0
引用数:
0
h-index:
0
WEISSMAN.G
DUKOR, P
论文数:
0
引用数:
0
h-index:
0
DUKOR, P
ZURIER, RB
论文数:
0
引用数:
0
h-index:
0
ZURIER, RB
[J].
NATURE-NEW BIOLOGY,
1971,
231
(22):
: 131
-
&
[25]
PROLIFERATION OF TYPE-2 ALVEOLAR CELLS - REVIEW OF COMMON RESPONSES IN TOXIC LUNG INJURY
WITSCHI, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL,QUEBEC,CANADA
UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL,QUEBEC,CANADA
WITSCHI, H
[J].
TOXICOLOGY,
1976,
5
(03)
: 267
-
277
[26]
1978, CRITERIA DOSE EFFECT
[27]
1974, CHROMIUM
←
1
2
3
→