INHIBITION OF FATTY ACID-SUPPORTED MITOCHONDRIAL RESPIRATION BY CYCLOSPORINE

被引：10

作者：

LEMMI, CAE

MILLER, RL

RAJFER, J

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT SURG,DIV UROL,TORRANCE,CA 90509

[2] ST JOHNS HEART INST,SANTA MONICA,CA 90404

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1990年 / 44卷 / 03期

关键词：

D O I：

10.1016/0885-4505(90)90071-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity. © 1990.

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收藏

页码：266 / 270

页数：5

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