INHIBITION-KINETICS OF BRAIN BUTYRYLCHOLINESTERASE BY CD2+ AND ZN2+, CA2+ OR MG2+ REACTIVATES THE INHIBITED ENZYME

被引：20

作者：

COKUGRAS, AN

TEZCAN, EF

机构：

[1] Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 08期

关键词：

D O I：

10.1016/0020-711X(93)90589-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The inhibition kinetics of sheep brain butyrylcholinesterase (BChE) (acylcholine acylhydrolase, EC 3.1.1.8) by Cd2+ and Zn2+ has been studied. 2. K(S) has been determined as 0.14 mM. Cd2+ and Zn2+ were the hyperbolic mixed-type inhibitors of BChE. Ca2+ and Mg2+ had no effect on the enzyme activity in the experimental conditions. 3. But when the enzyme was inhibited by 0.1 mM Cd2+ or Zn2+, Ca2+ and Mg2+ reactivated the inhibited form of BChE.

引用

页码：1115 / 1120

页数：6