STUDY OF 5-ARYLIDENE-2-THIOHYDANTOINS WITH POTENTIAL IMMUNOMODULATING AND ANTICANCER ACTIVITIES

被引：40

作者：

CHAZEAU, V

CUSSAC, M

BOUCHERLE, A

机构：

[1] FAC PHARM LA TRONCHE, PHARMACOCHIM MOLEC LAB, CHIM THERAPEUT LAB, F-38700 LA TRONCHE, FRANCE

[2] FAC PHARM MEYLAN, PHARMACOCHIM MOLEC GRP, CHIM ORGAN LAB, F-38240 MEYLAN, FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 06期

关键词：

2-THIOHYDANTOINS; IMMUNOMODULATOR; ANTICANCER AGENTS;

D O I：

10.1016/0223-5234(92)90140-V

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various 5-arylidene-2-thiohydantoins, N3-substituted and/or S-substituted or not, were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes or cyclic ketones and 2-thiohydantoins. These products, largely original, prepared as potentially active on chronic inflammatory diseases involving cellular-mediated immunity, display immunosuppressive activity which, however, remains clearly lower than ciclosporine's one. Searched in a few cases, anticancer activity is not obviously detected for any of tested products.

引用

页码：615 / 625

页数：11

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