ONLINE DIALYSIS AND WEAK CATION-EXCHANGE ENRICHMENT OF DIALYSATE - AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PHOLCODINE IN HUMAN PLASMA AND WHOLE-BLOOD

被引：23

作者：

ANDRESEN, AT ^{[1
]}

KROGH, M ^{[1
]}

RASMUSSEN, KE ^{[1
]}

机构：

[1] UNIV OSLO,INST PHARM,POB 1068,BLINDERN,N-0316 OSLO,NORWAY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 582卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(92)80310-M

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An automated method for the determination of pholcodine in plasma and whole blood is described. The technique combines dialysis and trace enrichment prior to high-performance liquid chromatography. Dialysis, trace enrichment on a weak cation-exchange column, separation on a cyano column and fluorescence detection was shown to be an extremely selective and sensitive method. The method has been used successfully in the analysis of real samples after administration of pholcodine. The automated method can be used, after minor modification, to determine other basic drugs in whole blood and plasma.

引用

页码：123 / 130

页数：8

共 8 条

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