SURFACTANT PROTEIN-D INTERACTS WITH PNEUMOCYSTIS-CARINII AND MEDIATES ORGANISM ADHERENCE TO ALVEOLAR MACROPHAGES

被引:133
作者
ORIORDAN, DM
STANDING, JE
KWON, KY
CHANG, D
CROUCH, EC
LIMPER, AH
机构
[1] MAYO CLIN & MAYO FDN,DIV PULM CRIT CARE & INTERNAL MED,THORAC DIS RES UNIT,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,DEPT BIOCHEM & MOLEC BIOL,ROCHESTER,MN 55905
[3] WASHINGTON UNIV,JEWISH HOSP ST LOUIS,DEPT PATHOL,ST LOUIS,MO 63110
关键词
PNEUMOCYSTIS CARINII; SURFACTANT PROTEIN D; GPA; MACROPHAGES; LECTIN;
D O I
10.1172/JCI117972
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Pneumocystis carinii interacts with glycoproteins present in the lower respiratory tract through its mannose-rich surface antigen complex termed gpA, Surfactant protein D (SP-D) is a recently described component of the airspace lining material that possesses a calcium-dependent lectin domain capable of interacting with glycoconjugates present on microorganisms and leukocytes, Accordingly, we evaluated the extent and localization of SP-D in the lower respiratory tract during Pneumocystis pneumonia in an immunosuppressed rat model and examined its role in modulating interaction of P. carinii with macrophages. We report that SP-D is a major component of the alveolar exudates that typify P. carinii pneumonia and is present bound to the surface of P. carinii organisms in vivo, We further demonstrate that SP-D binds to P. carinii through saccharide-mediated interactions with gpA present on the surface of the organism, Lastly, we show that SP-D augments binding of P. carinii to alveolar macrophages, but does not significantly enhance macrophage phagocytosis of the organism, The interaction of SPD with gpA represents an additional important component of the host-parasite relationship during P. carinii pneumonia.
引用
收藏
页码:2699 / 2710
页数:12
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