PSEUDOHYPOPARATHYROIDISM WITH RAISED PLASMA ALKALINE PHOSPHATASE

A case of pseudohypoparathyroidism is described which appears to show resistance to the action of parathyroid hormone on the kidney, but not to that on the bones. There was raised plasma phosphorus with renal phosphate retention, a low normal plasma calcium, and a raised alkaline phosphatase. Severe bone disease was present with radiological evidence of osteitis fibrosa. There was healing of the bone lesions, a fall in alkaline phosphatase, and restoration of calcium and phosphorus levels towards normal on treatment with large oral doses of calciferol.