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PRESENCE AND BINDING CHARACTERISTICS OF CALCITRIOL RECEPTORS IN HUMAN FETAL GUT

被引：8
作者：
DELVIN, EE
RICHARD, P
POTHIER, P
MENARD, D
机构：
[1] MCGILL UNIV,FAC MED,DEPT PHYSIOL,MONTREAL H3A 2T5,QUEBEC,CANADA
[2] CHU SHERBROOKE,FAC MED,DEPT ANAT & BIOL CELLULAIRE,SHERBROOKE J1H 5N4,QUEBEC,CANADA
[3] CHU SHERBROOKE,CTR RECH CLIN,SHERBROOKE J1H 5N4,QUEBEC,CANADA
来源：
FEBS LETTERS | 1990年 / 262卷 / 01期
关键词：
(Human fetus); Calcitriol receptor; Colon; Small intestine; Vitamin D;
D O I：
10.1016/0014-5793(90)80152-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, we show for the first time the presence of calcitriol-specific binding sites in hypertonic extracts of cells isolated from human fetal small intestine and colon from 13-21 weeks of gestation. Woolf plot analysis of the binding characteristics revealed the presence of a single class of high affinity receptors. The presence of specific receptors for calcitriol in fetal intestine and colon opens interesting possibilities as to the role of this hormone in human gut development. © 1990.
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页码：55 / 57
页数：3
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