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PROTEIN-KINASES

被引：63
作者：
GOLDSMITH, EJ
COBB, MH
机构：
[1] UNIV TEXAS, SW MED CTR, DEPT PHARMACOL, DALLAS, TX 75235 USA
[2] HOWARD HUGHES MED INST, DALLAS, TX USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 06期
关键词：
D O I：
10.1016/0959-440X(94)90264-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations, and binding of substrate analog inhibitors and autoinhibitory domains.
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页码：833 / 840
页数：8
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