SUPPRESSION OF HIPPOCAMPAL SYNAPTIC TRANSMISSION BY THE SPIDER TOXIN OMEGA-AGATOXIN-IV-A

被引：20

作者：

YAMAMOTO, C

SAWADA, S

OHNOSHOSAKU, T

机构：

[1] Department of Physiology, Faculty of Medicine, Kanazawa University, Kanazawa

来源：

BRAIN RESEARCH | 1994年 / 634卷 / 02期

关键词：

SYNAPSE; P-TYPE CALCIUM CHANNEL; TRANSMITTER RELEASE; AGATOXIN; MESSY FIBER; PERFORANT FIBER; HIPPOCAMPUS;

D O I：

10.1016/0006-8993(94)91942-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of omega-agatoxin-IV-A (AGTX) on synaptic transmissions were examined in thin transverse sections of the guinea pig hippocampus. AGTX suppressed, in a dose-dependent manner, field potentials elicited by messy fiber stimulation in CA3 pyramidal cell layer. AGTX also suppressed field potentials elicited by perforant fiber stimulation in granular layer without marked changes in antidromic responses. These results suggest that Ca2+ entry into presynaptic terminals via P-like calcium channels is at least partly responsible for release of glutamate.

引用

收藏

页码：349 / 352

页数：4

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