SYNTHESIS OF 4'-C-METHYLNUCLEOSIDES

被引：70

作者：

WAGA, T ^{[1
]}

NISHIZAKI, T ^{[1
]}

MIYAKAWA, I ^{[1
]}

OHRUI, H ^{[1
]}

MEGURO, H ^{[1
]}

机构：

[1] TOHOKU UNIV, FAC AGR, DEPT APPL BIOL CHEM, 1-1 TSUTSUMIDORI AMAMIYA, SENDAI 981, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 09期

关键词：

D O I：

10.1271/bbb.57.1433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several 4'-C-methylnucleosides were prepared. H-1-NMR studies on these nucleosides showed that they have the 3'-exo furanose ring conformation different from the 3'-endo conformation of natural nucleosides.

引用

页码：1433 / 1438

页数：6

共 16 条

[11] STRUCTURE OF NUCLEOCIDIN .3. (A NEW STRUCTURE)
MORTON, GO
LANCASTER, JE
VANLEAR, GE
FULMOR, W
MEYER, WE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (06) : 1535 - +
[12] ROBERT HM, 1992, J MED CHEM, V35, P1440
[13] PROBING INTERRELATION BETWEEN GLYCOSYL TORSION, SUGAR PUCKER, AND BACKBONE CONFORMATION IN C(8) SUBSTITUTED ADENINE-NUCLEOTIDES BY H-1 AND H-1-P-31 FAST FOURIER-TRANSFORM NUCLEAR MAGNETIC-RESONANCE METHODS AND CONFORMATIONAL ENERGY CALCULATIONS
SARMA, RH
LEE, CH
EVANS, FE
YATHINDRA, N
SUNDARALINGAM, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (23) : 7337 - 7348
[14] VERHEYDEN JPH, 1975, ANN NY ACAD SCI, V2255, P151
[15] VORBRUGGEN H, 1986, J MED CHEM, V29, P203
[16] 4'-SUBSTITUTED NUCLEOSIDES .4. SYNTHESIS OF SOME 4'-HYDROXYMETHYL NUCLEOSIDES
YOUSSEFYEH, RD
VERHEYDEN, JPH
MOFFATT, JG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (08) : 1301 - 1309

← 1 2 →