CORRELATION OF SYNERGISTIC CYTOTOXIC EFFECTS OF ENVIRONMENTAL CHEMICALS IN HUMAN FIBROBLASTS WITH THEIR LIPOPHILICITY

被引：15

作者：

WITTE, I ^{[1
]}

JACOBI, H ^{[1
]}

JUHLSTRAUSS, U ^{[1
]}

机构：

[1] UNIV OLDENBURG,ICBM,D-26111 OLDENBURG,GERMANY

来源：

CHEMOSPHERE | 1995年 / 31卷 / 09期

关键词：

D O I：

10.1016/0045-6535(95)80005-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The cytotoxic combination effects of 2,4-D with 12 xenobiotics having different lipophilicity were investigated in human fibroblasts at their no effect concentrations (NOEC). Each of the chemicals tested in binary combinations enhanced the toxicity of 2,4-D. These synergistic combination effects were independent of the chemical structure of the test compounds. However, the NOEC's of the xenobiotics used in the combinations varied by a factor of 10 000. For strongly lipophilic compounds the lowest NOEC's were needed to induce synergistic cytotoxicity. A linear regression analysis of the concentrations (NOEC's) of the 12 combined xenobiotics against their lipophilicity revealed a correlation with r = 0.96 for 11 agents. This close correlation may be explained by the membrane damaging properties of lipophilic compounds which enhance the uptake of hydrophilic agents.

引用

页码：4041 / 4049

页数：9

共 26 条

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