SENILE DEMENTIA, ALZHEIMER TYPE - A DISTINCT ENTITY IN THE IMMUNOSENESCENCE

被引：18

作者：

ANTONACI, S ^{[1
]}

GAROFALO, AR ^{[1
]}

CHICCO, C ^{[1
]}

POLIGNANO, AV ^{[1
]}

PUGLIESE, P ^{[1
]}

MISEFARI, A ^{[1
]}

JIRILLO, E ^{[1
]}

机构：

[1] UNIV MESSINA,SCH MED,I-98100 MESSINA,ITALY

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1990年 / 4卷 / 01期

关键词：

Aging; Alzheimer type; lymphocytes; lymphokines; monocytes; plaque‐forming cells; polymorphonuclear cells; senile dementia; T immunoregulation;

D O I：

10.1002/jcla.1860040106

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Since previous data have provided conflicting results on immunoresponsiveness in senile dementia, Alzheimer type (SDAT), we evaluated the immune function in groups of SDAT patients and aged and young donors. In comparison to the younger subjects, SDAT and aged subjects did not exhibit significant differences in lymphocyte surface markers. Both groups of aged donors showed decreased B cell polyclonal responsiveness in a nonspecific T cell‐driven B lymphocyte differentiation system. The use of an antigen‐specific induction assay revealed an imbalance of T helper (Th) or T suppressor function in the elderly, while SDAT individuals were characterized by decreased Th activity. At the same time, aged individuals manifested an impairment of leukocyte‐inhibiting factor (LIF) and lymphocyte‐derived chemotactic factor production; a selective deficit of LIF release was seen in SDAT. Finally, elderly individuals displayed a decline of polymorphonuclear cell (PMN)‐mediated functions and monocyte phagocytosis; only a decrease in PMN response was observed in SDAT. These results reveal discrepancies in impaired immune responses between SDAT and aging. Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company

引用

页码：16 / 21

页数：6