The limited universe of exons

被引：25

作者：

Dorit, Robert L. ^{[1
]}

Gilbert, Walter ^{[2
]}

机构：

[1] Yale Univ, Dept Biol, Osborn Mem Labs, POB 6666, New Haven, CT 06511 USA

[2] Harvard Univ, Dept Cellular & Dev Biol, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(05)80193-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The catalogue of mosaic proteins showing evidence of exon-shuffling continues to expand. The repeated use of exon modules suggests that current protein diversity could have been generated from a finite set of such exon modules, and that the size and character of this underlying exon universe can still be glimpsed in extant proteins.

引用

页码：464 / 469

页数：6

共 77 条

[31] DENOVO DESIGN, EXPRESSION, AND CHARACTERIZATION OF FELIX - A 4-HELIX BUNDLE PROTEIN OF NATIVE-LIKE SEQUENCE
HECHT, MH
RICHARDSON, JS
RICHARDSON, DC
OGDEN, RC
[J]. SCIENCE, 1990, 249 (4971) : 884 - 891
[32] CRYSTAL-STRUCTURE OF ALPHA-1 - IMPLICATIONS FOR PROTEIN DESIGN
HILL, CP
ANDERSON, DH
WESSON, L
DEGRADO, WF
EISENBERG, D
[J]. SCIENCE, 1990, 249 (4968) : 543 - 546
[33] RELATED FIBROBLAST GROWTH-FACTOR RECEPTOR GENES EXIST IN THE HUMAN GENOME
HOUSSAINT, E
BLANQUET, PR
CHAMPIONARNAUD, P
GESNEL, MC
TORRIGLIA, A
COURTOIS, Y
BREATHNACH, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (20) : 8180 - 8184
[34] HUHTALA P, 1990, J BIOL CHEM, V265, P11077
[35] DIVERSITY OF THE IMMUNOGLOBULIN GENE SUPERFAMILY
HUNKAPILLER, T
HOOD, L
[J]. ADVANCES IN IMMUNOLOGY, 1989, 44 : 1 - 63
[36] THE GROWING IMMUNOGLOBULIN GENE SUPERFAMILY
HUNKAPILLER, T
HOOD, L
[J]. NATURE, 1986, 323 (6083) : 15 - 16
[37] ISHIKAWA N, 1990, J BIOL CHEM, V265, P19040
[38] COMPARTMENTALIZED ISOZYME GENES AND THE ORIGIN OF INTRONS
IWABE, N
KUMA, K
KISHINO, H
HASEGAWA, M
MIYATA, T
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1990, 31 (03) : 205 - 210
[39] MOLECULAR ANATOMY - PHYLETIC RELATIONSHIPS DERIVED FROM 3-DIMENSIONAL STRUCTURES OF PROTEINS
JOHNSON, MS
SUTCLIFFE, MJ
BLUNDELL, TL
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1990, 30 (01) : 43 - 59
[40] JOHNSON MS, 1990, METHOD ENZYMOL, V183, P670

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